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(FRAME-INFO (STRING "Free Nerve Endings. (Image compliments of Dr. M. Byers, Dept. of Biological Structure, University of Washington\). The majority of somatosensory receptors are free \(\"naked\"\) nerve \(axon\) endings; they are found throughout the body, not just in the skin. They can be sensitive to tissue damage, and are thereby detectors of painful stimuli \(nociceptors\). They are also responsive to temperature, itch and tickle. The free axon endings shown in the epithelial papillae of the tongue are stained immunocytochemically for calcitonin gene-related peptide; pre-terminal axons can be seen in the submucosa."))